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Antioxidants + zinc

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Funders: Centers for Disease Control and Prevention and others
  • Human trial1

Associations

2

Visual acuity loss

downin humans1OR 0.73

1 study

  1. Antioxidants + zinc lowers the risk of visual acuity loss in humans (OR 0.73, 99% CI 0.54-0.99).

    “The only statistically significant reduction in rates of at least moderate visual acuity loss occurred in persons assigned to receive antioxidants plus zinc (OR, 0.73; 99% CI, 0.54-0.99).”

    Human trialtablets6.3 years

    A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

    Archives of ophthalmology (Chicago, Ill. : 1960)1 Oct 2001

Age-related macular degeneration

downin humans1OR 0.72

1 study

  1. Antioxidants + zinc lowers the risk of age-related macular degeneration in humans (OR 0.72, 99% CI 0.52-0.98).

    “Comparison with placebo demonstrated a statistically significant odds reduction for the development of advanced AMD with antioxidants plus zinc (odds ratio [OR], 0.72; 99% confidence interval [CI], 0.52-0.98).”

    Human trialtablets6.3 years

    A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

    Archives of ophthalmology (Chicago, Ill. : 1960)1 Oct 2001

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