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Antibiotic treatment

Antibiotic treatment has been studied in 3 papers since 2019: 1 trial in people, 2 in animals; 1 in the past year. The newest story, Nov 1, 2026: “Eflornithine may lower a DNA damage marker in stomach lesions”.

Intervention

3 papers study it3 findingsUpdated

See all 3 papers on antibiotic treatment

At a glance

The findings reach worms or flies, none yet in people. 2 independent labs in 2 countries.

None of its findings points the other way.

Worms or flies: a single group. Cells, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: National Institute of Allergy and Infectious Diseases and 4 more
  • 1 of 2 findings with company ties
  • Human trial1
  • Model organisms2

What did studies of antibiotic treatment find?

2

Studies of antibiotic treatment measured 2 outcomes; the most studied are mortality (1 study) and lifespan (1).

Mortality

downin A. stephensi1

1 study

  1. Antibiotic treatment decreases mortality in Δaslrim1 mosquitoes.

    “The survival rate of Δaslrim1 mosquitoes and their ability to support PfSPZ development, were partially restored by antibiotic treatment”

    Model organismsin Δaslrim1 mosquitoes

    Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals its unexpected role in reproduction and vector competence

    PLoS pathogens

Lifespan

upin flies1

1 study

  1. Antibiotic treatment extends lifespan in flies (axenic flies generated by antibiotic treatment; without detrimental effects).

    “The removal of microbes by using bleaching and antibiotic treatments without detrimental effects increased fly lifespan.”

    Model organismsaxenic flies generated by antibiotic treatment; without detrimental effects

    The role of commensal microbes in the lifespan of Drosophila melanogaster

    Aging

What is antibiotic treatment linked with?

1

Studies link antibiotic treatment with 1 measure, most often Gut microbiome composition and function (1 study).

Gut microbiome composition and function

mixedin mammals1

1 study

  1. Antibiotic treatment is associated with gut microbiome composition and function in mammals.

    “Aspects of the so-called 'Western' lifestyle linked to disease risk such as energy dense diet and antibiotic treatment are known to affect the composition and function of the microbiome.”

    Review

    The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom

    Journal of internal medicine

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 01 paper in 12 months
Cancer Prevention Research

Eflornithine may lower a DNA damage marker in stomach lesions

Between months 18 and 24, after treatment ended, DNA damage marker scores fell 18.3 points with eflornithine versus 1.6 with placebo.Between months 18 and 24, after treatment ended, DNA damage marker scores fell 18.3 points with eflornithine versus 1.6 with placebo.

Randomized trial · 55 peopleInterventions
Paper

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