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Aminolevulinic acid photodynamic therapy

Intervention

1 paper studies it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 3 more
  • Human trial1

Outcomes

3

Immune response

upin humans1

1 study

  1. Aminolevulinic acid photodynamic therapy improves immune response in humans.

    “Additionally, ALA-PDT restored the antigen presentation and migration function of dendritic cells and enhanced cell-cell communication among immune cells.”

    Human trialphotoaged skinskin6 months

    Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin

    Frontiers in immunologyJun 19, 2023

More on Immune response

M1/M2 macrophage ratio

upin humans1

1 study

  1. Aminolevulinic acid photodynamic therapy increases M1/M2 macrophage ratio in humans.

    “The ratio of M1/M2 and percentage of Langerhans cells also decreased with photoaging and increased after ALA-PDT.”

    Human trialphotoaged skinskin6 months

    Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin

    Frontiers in immunologyJun 19, 2023

More on M1/M2 macrophage ratio

Cellular senescence

downin humans1

1 study

  1. Aminolevulinic acid photodynamic therapy decreases cellular senescence in humans.

    “ALA-PDT has potential to rejuvenate immune cells, partially reversed immunosenescence and improved the immunosuppressive state, ultimately remodelling the immune microenvironment in photoaged skin.”

    Human trialphotoaged skinskin6 months

    Single cell transcriptome profiling reveals cutaneous immune microenvironment remodeling by photodynamic therapy in photoaged skin

    Frontiers in immunologyJun 19, 2023

More on Cellular senescence

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