Alpha-1 antitrypsin
Alpha-1 antitrypsin has been studied in 2 papers since 2022: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Sep 22, 2022: “Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult Drosophila”.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institutes of Health and 1 more
- Model organisms2
What did studies of Alpha-1 antitrypsin find?
2Studies of Alpha-1 antitrypsin measured 2 outcomes; the most studied are NF-κB signaling (2 studies) and RELA (1).
NF-κB signaling
downin human cells2
2 studies
NF-κB signaling
downin human cells2
Alpha-1 antitrypsin inhibits NF-κB signaling in human cells.
“the first detectable impact of hAAT treatment was the inhibition of the nuclear activity of NF-κB.”
Cellsin human senescent cells
Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult Drosophila
Biomolecules
Alpha-1 antitrypsin inhibits NF-κB signaling in human cells.
“the first detectable impact of hAAT treatment was the inhibition of the nuclear activity of NF-ĸB.”
Cellssenescent cells
Human Alpha 1 Antitrypsin Suppresses NF-ĸB Activity and Extends Lifespan in Adult Drosophila
Research SquarePreprint
RELA
downin human cells1
1 study
RELA
downin human cells1
Alpha-1 antitrypsin decreases RELA in human cells.
“hAAT treatment suppressed the mRNA levels of NF-κB-targeted genes, as well as NF-κB itself (P65 and P50), in human senescent cells.”
Cellsin human senescent cells
Human Alpha 1 Antitrypsin Suppresses NF-κB Activity and Extends Lifespan in Adult Drosophila
Biomolecules