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Allicin

Intervention

1 paper5 findings

PubChem 65036ChEBI 28411MeSH C006452

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Deanship of Scientific Research, King Khalid University and 1 more
  • Animals1

Outcomes

5

NFE2L2

upin rats1

1 study

  1. Allicin increases NFE2L2 in rats.

    “Allicin treatment alleviated these issues by restoring neurotransmitter function, boosting antioxidant defenses, reducing inflammation and amyloid burden, and upregulating BDNF and NrF2 expressions.”

    Animalsin aged ratsbrain20 mg/kg and 40 mg/kg8 weeksmales

    Allicin attenuates age-related cognitive and neural decline in a rat model by modulating amyloid burden and regulating BDNF/NrF2 gene expression

    Tissue & cell29 Oct 2025

More on NFE2L2

BDNF

upin rats1

1 study

  1. Allicin increases BDNF in rats.

    “Allicin treatment alleviated these issues by restoring neurotransmitter function, boosting antioxidant defenses, reducing inflammation and amyloid burden, and upregulating BDNF and NrF2 expressions.”

    Animalsin aged ratsbrain20 mg/kg and 40 mg/kg8 weeksmales

    Allicin attenuates age-related cognitive and neural decline in a rat model by modulating amyloid burden and regulating BDNF/NrF2 gene expression

    Tissue & cell29 Oct 2025

More on BDNF

Inflammation

downin rats1

1 study

  1. Allicin decreases inflammation in rats.

    “Allicin treatment alleviated these issues by restoring neurotransmitter function, boosting antioxidant defenses, reducing inflammation and amyloid burden, and upregulating BDNF and NrF2 expressions.”

    Animalsin aged ratsbrain20 mg/kg and 40 mg/kg8 weeksmales

    Allicin attenuates age-related cognitive and neural decline in a rat model by modulating amyloid burden and regulating BDNF/NrF2 gene expression

    Tissue & cell29 Oct 2025

More on Inflammation

Amyloid-beta 1-42

downin rats1

1 study

  1. Allicin decreases amyloid-beta 1-42 in rats.

    “Allicin treatment alleviated these issues by restoring neurotransmitter function, boosting antioxidant defenses, reducing inflammation and amyloid burden, and upregulating BDNF and NrF2 expressions.”

    Animalsin aged ratsbrain20 mg/kg and 40 mg/kg8 weeksmales

    Allicin attenuates age-related cognitive and neural decline in a rat model by modulating amyloid burden and regulating BDNF/NrF2 gene expression

    Tissue & cell29 Oct 2025

More on Amyloid-beta 1-42

Cognitive function

upin rats1

1 study

  1. Allicin improves cognitive function in rats.

    “Allicin treatment alleviated these issues by restoring neurotransmitter function, boosting antioxidant defenses, reducing inflammation and amyloid burden, and upregulating BDNF and NrF2 expressions.”

    Animalsin aged ratsbrain20 mg/kg and 40 mg/kg8 weeksmales

    Allicin attenuates age-related cognitive and neural decline in a rat model by modulating amyloid burden and regulating BDNF/NrF2 gene expression

    Tissue & cell29 Oct 2025

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