Aldehyde 13-13
1 paper5 findings
- 1 lab in 1 country
- Funders: Military Institute of Science and Technology and 3 more
- Model organisms1
Outcomes
4Lifespan
upin worms1upin yeast cells1
1 study
Lifespan
upin worms1upin yeast cells1
Aldehyde 13-13 extends lifespan in yeast cells.
“aldehyde 13-13 increased the lifespan of Caenorhabditis elegans and budding yeast”
Cells
OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells
Pharmaceuticals (Basel, Switzerland)Aug 29, 2023
Aldehyde 13-13 extends lifespan in worms.
“aldehyde 13-13 increased the lifespan of Caenorhabditis elegans and budding yeast”
Model organisms
OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells
Pharmaceuticals (Basel, Switzerland)Aug 29, 2023
Apoptosis
upin human cells1
1 study
Apoptosis
upin human cells1
Aldehyde 13-13 induces apoptosis in human cells.
“aldehyde 13-13 induced apoptosis of H2O2-induced senescent cells, compared with non-senescent normal cells”
CellsH2O2-induced senescent cells compared with non-senescent normal cells
OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells
Pharmaceuticals (Basel, Switzerland)Aug 29, 2023
Cell proliferation
upin human cells1
1 study
Cell proliferation
upin human cells1
Aldehyde 13-13 increases cell proliferation in human cells.
“activation of OR2H2 by aldehyde 13-13 restored proliferation”
CellsH2O2-induced senescent cells
OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells
Pharmaceuticals (Basel, Switzerland)Aug 29, 2023
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Aldehyde 13-13 decreases cellular senescence in human cells.
“reduced the expression of senescence markers, P16 and P19”
CellsH2O2-induced senescent cells
OR2H2 Activates CAMKKβ-AMPK-Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 Cells
Pharmaceuticals (Basel, Switzerland)Aug 29, 2023