Aged small intestine-derived small extracellular vesicles

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Jiangsu Commission of Health and 1 more

Animals1

Outcomes

adipogenesis

upin mice1

1 study

Aged small intestine-derived small extracellular vesicles induce adipogenesis in mice.
“promoted adipogenic differentiation of fibro-adipogenic progenitors (FAPs)”
Animalsin vitro exposure or in vivo administration
Aged Small Intestine Derived Small Extracellular Vesicles miR-214-3p Leads to Intermuscular Fatty Infiltration Through Wnt/β-Catenin Mediated Fibro-Adipogenic Progenitors Adipogenesis
FASEB journal : official publication of the Federation of American Societies for Experimental Biology3 Feb 2026

Intermuscular adipose tissue infiltration

upin mice1

1 study

Aged small intestine-derived small extracellular vesicles increase intermuscular adipose tissue infiltration in mice.
“increasing IMAT infiltration and decreasing muscle strength in young recipient mice”
Animalstail-vein administrationskeletal muscle
Aged Small Intestine Derived Small Extracellular Vesicles miR-214-3p Leads to Intermuscular Fatty Infiltration Through Wnt/β-Catenin Mediated Fibro-Adipogenic Progenitors Adipogenesis
FASEB journal : official publication of the Federation of American Societies for Experimental Biology3 Feb 2026

Muscle strength

downin mice1

1 study

Aged small intestine-derived small extracellular vesicles decrease muscle strength in mice.
“decreasing muscle strength in young recipient mice”
Animalstail-vein administrationskeletal muscle
Aged Small Intestine Derived Small Extracellular Vesicles miR-214-3p Leads to Intermuscular Fatty Infiltration Through Wnt/β-Catenin Mediated Fibro-Adipogenic Progenitors Adipogenesis
FASEB journal : official publication of the Federation of American Societies for Experimental Biology3 Feb 2026

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FASEB Journal3 Feb