AgingResearch.NewsJoin free

Aged hematopoietic stem cells

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Deutsche Forschungsgemeinschaft
  • Animals1

Outcomes

1

Clonality

no changein mice1

1 study

  1. Aged hematopoietic stem cells have no effect on clonality in mice.

    “transplanted aged HSCs showed no changes in clonality, regardless of recipient age or pre-conditioning.”

    Animalsregardless of recipient age or pre-conditioning

    The impact of donor and recipient age on post-transplantation clonality in murine hematopoiesis

    Stem cells (Dayton, Ohio)4 Sep 2025

Associations

1

Myeloid lineage bias

upin mice1

1 study

  1. Aged hematopoietic stem cells are associated with myeloid lineage bias in mice.

    “myeloid lineage bias, a hallmark of aged HSCs, was confirmed at a clonal level across all experimental groups.”

    Animalspost-transplantation across all experimental groups

    The impact of donor and recipient age on post-transplantation clonality in murine hematopoiesis

    Stem cells (Dayton, Ohio)4 Sep 2025

Latest

Related