Aerobic and muscle-strengthening exercise

Intervention

1 paper6 findings

  • 1 lab in 1 country
  • Human trial1

Outcomes

6

Lung volumes and spirometry other than forced vital capacity

no changein humans1

1 study
  1. Aerobic and muscle-strengthening exercise has no effect on lung volumes and spirometry other than forced vital capacity in humans.

    “No significant changes were observed in spirometry or lung volumes, except for a small increase in FVC”

    Human trialCOPD; single-arm before-and-after comparisonlung3 sessions/week12 weeksn = 62

    Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    Respiratory research12 Oct 2026

Symptom burden

downin humans1

1 study
  1. Aerobic and muscle-strengthening exercise decreases symptom burden in humans (CAT −1.0; CCQ −0.1).

    “while symptom burden decreased (ΔCAT = - 1.0, p = 0.014; ΔCCQ = - 0.1, p = 0.011)”

    Human trialCOPD; single-arm before-and-after comparison3 sessions/week12 weeksn = 62

    Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    Respiratory research12 Oct 2026

1-minute sit-to-stand repetitions

upin humans1

1 study
  1. Aerobic and muscle-strengthening exercise increases 1-minute sit-to-stand repetitions in humans (+3 repetitions).

    “Exercise capacity improved (Δ6MWT = + 15 m, p = 0.002; Δ1STS = + 3 repetitions, p < 0.0001)”

    Human trialCOPD; single-arm before-and-after comparison3 sessions/week12 weeksn = 62

    Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    Respiratory research12 Oct 2026

More on 1-minute sit-to-stand repetitions

6-minute walk distance

upin humans1

1 study
  1. Aerobic and muscle-strengthening exercise increases 6-minute walk distance in humans (+15 m).

    “Exercise capacity improved (Δ6MWT = + 15 m, p = 0.002; Δ1STS = + 3 repetitions, p < 0.0001)”

    Human trialCOPD; single-arm before-and-after comparison3 sessions/week12 weeksn = 62

    Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    Respiratory research12 Oct 2026

More on 6-minute walk distance

Forced vital capacity

upin humans1

1 study
  1. Aerobic and muscle-strengthening exercise increases forced vital capacity in humans (+0.12 z-score).

    “except for a small increase in FVC (Δ = 0.12 z-score, p = 0.027)”

    Human trialCOPD; single-arm before-and-after comparisonlung3 sessions/week12 weeksn = 62

    Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    Respiratory research12 Oct 2026

More on Forced vital capacity

Peripheral airway mechanics

upin humans1

1 study
  1. Aerobic and muscle-strengthening exercise improves peripheral airway mechanics in humans (R5 −0.75 z-score; R5-R20 −0.18 z-score; Fres −0.33 Hz; AX −0.05 kPa·s−1).

    “IOS measures improved after the exercise intervention, suggesting physiological adaptations beyond skeletal muscle conditioning that resulted in improved airway mechanics and ventilation distribution in the peripheral lung”

    Human trialCOPD; single-arm before-and-after comparisonsupervised, individually tailored moderate-intensity programperipheral lung3 sessions/week12 weeksn = 62

    Improvement in peripheral airway function after a 12-week exercise intervention in COPD

    Respiratory research12 Oct 2026

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