Adult loneliness

Exposure

2 papers study it2 findings

Across all fields, 2 papers: 2 observational studies in people

  • 1 lab in 2 countries
  • Humans2

Outcomes

2

Dementia

mediatesin humans1

1 study
  1. Adult loneliness mediates dementia in humans (17.2% (95% CI, 4.9%-29.5%)).

    “17.2% (95% CI, 4.9%-29.5%) of the association with dementia risk”

    Humansin association between childhood loneliness and dementia riskup to 7 yearsn = 13,592

    Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults

    JAMA network open

More on Dementia

Cognitive function

mediatesin humans1

1 study
  1. Adult loneliness mediates cognitive function in humans (8.5% (95% CI, 2.9% to 14.1%)).

    “Adult loneliness mediated 8.5% (95% CI, 2.9% to 14.1%) of the association of childhood loneliness with cognitive decline”

    Humansin association between childhood loneliness and cognitive declineup to 7 yearsn = 13,592

    Childhood Loneliness and Cognitive Decline and Dementia Risk in Middle-Aged and Older Adults

    JAMA network open

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 11 paper in 12 months
Brain, Behavior, & Immunity - Health

Inflammation linked to stress-related thinking differences

Observational analyses of two adult cohorts, with 209–276 and up to 132,068 participants, found patterns consistent with inflammation partly linking childhood abuse and…Observational analyses of two adult cohorts, with 209–276 and up to 132,068 participants, found patterns consistent with inflammation partly linking childhood abuse and thinking scores.

Cross-sectional studyInflammation