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Accommodative stimuli

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Humans1

Outcomes

2

Lens thickness

upin humans1

1 study

  1. Accommodative stimuli increases lens thickness in humans.

    “During accommodation, the anterior and posterior curvatures of the lens decrease, while its thickness increases.”

    Humansduring accommodationcrystalline lens0, -1, -2, -3, and -6 Dn = 300

    In vivo characterization of morphologic changes in the lens during accommodation as a function of age by use of OCT with swept-source technology

    Japanese journal of ophthalmology7 Jul 2025

Anterior and posterior lens radii

downin humans1

1 study

  1. Accommodative stimuli decreases anterior and posterior lens radii in humans.

    “Structural changes in the lens were observed, specifically in the anterior and posterior radii, which decreased with accommodation”

    Humansduring accommodationcrystalline lens0, -1, -2, -3, and -6 Dn = 300

    In vivo characterization of morphologic changes in the lens during accommodation as a function of age by use of OCT with swept-source technology

    Japanese journal of ophthalmology7 Jul 2025

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