AAV9-MEDIATED ANTI-MIR-59

AAV9-MEDIATED ANTI-MIR-59 extends lifespan in mice (+25.5% longevity).

“yielded a 25.5% increase in longevity of LmnaG609G/G609G mice.”

Animalsin LmnaG609G/G609G mice

Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice

The EMBO journal·Nov 16, 2022

AAV9-MEDIATED ANTI-MIR-59 prevents epidermal thinning in mice.

“suppressed epidermal thinning and dermal fat loss”

Animalsin LmnaG609G/G609G miceskin

Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice

The EMBO journal·Nov 16, 2022

AAV9-MEDIATED ANTI-MIR-59 decreases fibrosis in mice.

“Treatment with AAV9-mediated anti-miR-59 reduced fibrosis in the quadriceps muscle, heart, and aorta”

Animalsin LmnaG609G/G609G micequadriceps muscle, heart, aorta

Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in mice

The EMBO journal·Nov 16, 2022