AAV-SH-SREBF1

1 paper1 finding

1 lab in 1 country

Funders: National Natural Science Foundation of China and 1 more

Animals1

Outcomes

1

Cellular senescence

downin mice1

1 study

AAV-SH-SREBF1 decreases cellular senescence in mice.
“local delivery of lentivirus or AAV-mediated VSMC specific expressing sh-Srebf1 significantly attenuates the senescence-like transformation of VSMC both in vitro and in vivo”
Animalslocal delivery of lentivirus or AAV-mediated VSMC specific expressing sh-Srebf1carotid artery
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling
Nature communicationsDec 26, 2025

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