AAV-IGF1
Intervention1 paper3 findings
- Animals1
Outcomes
3DCX
no changein rats1Very low certainty
1 study
DCX
no changein rats1Very low certainty
AAV-IGF1 has no effect on DCX in rats.
“However, molecular analyses of DCX expression did not reveal significant changes, and IBA‐1 marker have yet to be analysed.”
Animalsaged ratsAAV-gfaABC1D-IGF1-TdTomatohippocampus52 daysfemales
Modulation of hippocampal astrocytes in aged rats through insulin‐growth factor 1 gene therapy · AAIC 2025 abstract · 23 Dec 2025
Long-term object recognition
upin rats1Very low certainty
1 study
Long-term object recognition
upin rats1Very low certainty
AAV-IGF1 improves long-term object recognition in rats.
“aged rats with hippocampal astrocytes overexpressing IGF1 exhibited improvements in certain behaviours, including increased rearing, enhanced long‐term object recognition, and improved spatial memory.”
Animalsaged ratsAAV-gfaABC1D-IGF1-TdTomatohippocampus52 daysfemales
Modulation of hippocampal astrocytes in aged rats through insulin‐growth factor 1 gene therapy · AAIC 2025 abstract · 23 Dec 2025
Spatial memory
upin rats1Very low certainty
1 study
Spatial memory
upin rats1Very low certainty
AAV-IGF1 improves spatial memory in rats.
“aged rats with hippocampal astrocytes overexpressing IGF1 exhibited improvements in certain behaviours, including increased rearing, enhanced long‐term object recognition, and improved spatial memory.”
Animalsaged ratsAAV-gfaABC1D-IGF1-TdTomatohippocampus52 daysfemales
Modulation of hippocampal astrocytes in aged rats through insulin‐growth factor 1 gene therapy · AAIC 2025 abstract · 23 Dec 2025