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AAV-HDAC3

Intervention

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 1 more
  • Animals1

Outcomes

1

Osteoarthritis

downin mice1

1 study

  1. AAV-HDAC3 decreases osteoarthritis in mice.

    “intra-articular injection with an HDAC3-expressing adeno-associated virus restored the young phenotype of the aged chondrocytes stimulated by ECM stiffening and alleviated OA in mice”

    Animalsadeno-associated viruscartilage

    Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3

    Bone researchMay 24, 2024

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