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5z-7-oxozeaenol

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Key Research and Development Program of Zhejiang Province
  • Animals1

Outcomes

3

Retinal function

upin rats1

1 study

  1. 5z-7-oxozeaenol improves retinal function in rats.

    “greatly improved a-waves, b-waves, and OP values, as recorded by electroretinography”

    Animalslaser-induced CNVretina

    Senescent retinal pigment epithelial cells promote angiogenesis in choroidal neovascularization via the TAK1/p38 MAPK pathway

    Experimental eye research6 Jan 2025

Choroidal neovascularization

downin rats1

1 study

  1. 5z-7-oxozeaenol decreases choroidal neovascularization in rats.

    “inhibiting the activity of TAK1 using 5Z-7-oxozeaenol significantly alleviated CNV lesion formation and fluorescein leakage in fundus fluorescein angiography”

    Animalslaser-induced CNVchoroid

    Senescent retinal pigment epithelial cells promote angiogenesis in choroidal neovascularization via the TAK1/p38 MAPK pathway

    Experimental eye research6 Jan 2025

More on Choroidal neovascularization

Angiogenesis

downin human cells1

1 study

  1. 5z-7-oxozeaenol inhibits angiogenesis in human cells.

    “the TAK1 inhibitors 5Z-7-oxozeaenol and takinib reversed the effects of conditioned media from senescent ARPE-19 cells on the wound healing, migration, survival, and tube formation abilities of HUVECs”

    Cellsconditioned media from senescent ARPE-19 cells

    Senescent retinal pigment epithelial cells promote angiogenesis in choroidal neovascularization via the TAK1/p38 MAPK pathway

    Experimental eye research6 Jan 2025

More on Angiogenesis

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