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4,4'-methylenediphenol

Intervention

1 paper6 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Model organisms1

Outcomes

6

Lipofuscin

downin worms1

1 study

  1. 4,4'-methylenediphenol decreases lipofuscin in worms.

    “4,4'-methylenediphenol treatment also reduced the contents of reactive oxygen species (ROS) and lipofuscin, and decreased Aβ protein deposition in the worms.”

    Model organismsAlzheimer's disease model worms

    4,4'-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer's disease

    Frontiers in aging neuroscience30 May 2024

More on Lipofuscin

DAF-16 nuclear translocation

upin worms1

1 study

  1. 4,4'-methylenediphenol increases daf-16 nuclear translocation in worms.

    “4,4'-methylenediphenol promoted the nuclear translocation of DAF-16”

    Model organismsGFP reporter worms

    4,4'-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer's disease

    Frontiers in aging neuroscience30 May 2024

Aβ protein deposition

downin worms1

1 study

  1. 4,4'-methylenediphenol decreases Aβ protein deposition in worms.

    “4,4'-methylenediphenol treatment also reduced the contents of reactive oxygen species (ROS) and lipofuscin, and decreased Aβ protein deposition in the worms.”

    Model organismsAlzheimer's disease model worms

    4,4'-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer's disease

    Frontiers in aging neuroscience30 May 2024

More on Aβ protein deposition

Reactive oxygen species

downin worms1

1 study

  1. 4,4'-methylenediphenol decreases reactive oxygen species in worms.

    “4,4'-methylenediphenol treatment also reduced the contents of reactive oxygen species (ROS) and lipofuscin, and decreased Aβ protein deposition in the worms.”

    Model organismsAlzheimer's disease model worms

    4,4'-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer's disease

    Frontiers in aging neuroscience30 May 2024

More on Reactive oxygen species

Motility

upin worms1

1 study

  1. 4,4'-methylenediphenol improves motility in worms.

    “4,4'-Methylenediphenol not only delayed paralysis onset and senescence in the AD model worms but also enhanced their motility and stress tolerance.”

    Model organismsAlzheimer's disease model worms

    4,4'-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer's disease

    Frontiers in aging neuroscience30 May 2024

Paralysis onset

downin worms1

1 study

  1. 4,4'-methylenediphenol decreases paralysis onset in worms.

    “4,4'-Methylenediphenol not only delayed paralysis onset and senescence in the AD model worms but also enhanced their motility and stress tolerance.”

    Model organismsAlzheimer's disease model worms

    4,4'-methylenediphenol reduces Aβ-induced toxicity in a Caenorhabditis elegans model of Alzheimer's disease

    Frontiers in aging neuroscience30 May 2024

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