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3/689

Intervention

1 paper studies it4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Biotechnology and Biological Sciences Research Council and 5 more
  • Cells1

Outcomes

4

DNA damage response

downin human cells1

1 study

  1. 3/689 protects against DNA damage response in human cells.

    “hMSC treated with 3/689 showed enhanced protection from DNA damage”

    Cellsin hMSC expanded in the presence of 3/689mesenchymal stem cell

    A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice

    Stem cells (Dayton, Ohio)

More on DNA damage response

Bone marrow engraftment

upin mice1

1 study

  1. 3/689 increases bone marrow engraftment in mice (10-fold).

    “These cells showed a 10-fold increase in engraftment levels in bone marrow 5 weeks post-transplant”

    Animalsbone marrow5 weeks post-transplant

    A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice

    Stem cells (Dayton, Ohio)

Cell proliferation

upin human cells1

1 study

  1. 3/689 increases cell proliferation in human cells (300-fold).

    “cultures produced a 300-fold increase in the number of cells generated”

    Cellsexpanded in the presence of small molecule 3/689mesenchymal stem cell

    A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice

    Stem cells (Dayton, Ohio)

Replicative lifespan

upin human cells1

1 study

  1. 3/689 extends replicative lifespan in human cells (up to 10 population doublings).

    “extended lifespan up to 10 population doublings”

    Cellsin hMSC following ex vivo expansionmesenchymal stem cell

    A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice

    Stem cells (Dayton, Ohio)

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