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20-hydroxyecdysone

Intervention

1 paper2 findings

PubChem 5459840ChEBI 16587

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Korea Food Research Institute and 3 more
  • Model organisms1

Outcomes

2

O-GlcNAc

upin flies1

1 study

  1. 20-hydroxyecdysone increases O-GlcNAc in flies.

    “both genetic overexpression of EcR and exogenous 20-hydroxyecdysone treatment promote ISC proliferation and increase O-GlcNAc levels.”

    Model organismsmidgut

    Integrated ecdysone and O-linked N-acetylglucosamine signaling coordinates intestinal stem cell proliferation in Drosophila midgut

    G3 (Bethesda, Md.)19 Aug 2025

More on O-GlcNAc

Intestinal stem cell proliferation

upin flies1

1 study

  1. 20-hydroxyecdysone increases intestinal stem cell proliferation in flies.

    “both genetic overexpression of EcR and exogenous 20-hydroxyecdysone treatment promote ISC proliferation and increase O-GlcNAc levels.”

    Model organismsmidgut

    Integrated ecdysone and O-linked N-acetylglucosamine signaling coordinates intestinal stem cell proliferation in Drosophila midgut

    G3 (Bethesda, Md.)19 Aug 2025

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