2-hydroxybutyric acid

2 papers study it2 more mention it6 findings

Outcomes

Oxidative capacity

upin animals2

2 studies

2-hydroxybutyric acid improves oxidative capacity.
“This response to 2HB exposure leads to an improved oxidative capacity both in vitro and in vivo”
Animals
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
eLifeNov 24, 2023Preprint
2-hydroxybutyric acid improves oxidative capacity.
“This response to 2HB exposure leads to an improved oxidative capacity both in vitro and in vivo”
Animals
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
bioRxiv (Cold Spring Harbor Laboratory)Oct 19, 2023Preprint

Nuclear protein ADP-ribosylation

downin cells2

2 studies

2-hydroxybutyric acid decreases nuclear protein ADP-ribosylation in cells.
“The 2HB-induced decrease in nuclear protein ADP-ribosylation leads to a C/EBPβ mediated transcriptional response in the branched-chain amino acid degradation pathway.”
Cells
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
eLifeNov 24, 2023Preprint
2-hydroxybutyric acid decreases nuclear protein ADP-ribosylation in cells.
“2HB-induced decrease in nuclear protein ADP-ribosylation leads to a C/EBPβ mediated transcriptional response”
Cells
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
bioRxiv (Cold Spring Harbor Laboratory)Oct 19, 2023Preprint

BCAT1

downin cells1

1 study

2-hydroxybutyric acid inhibits BCAT1 in cells.
“2HB directly inhibits branched- chain aminotransferase enzymes”
Cells
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
eLifeNov 24, 2023Preprint