2-aminoethoxydiphenyl borate

1. 2-aminoethoxydiphenyl borate decreases Ca2+ overload in cells.

   “NSUN2 induced Ca2+ overload, which was mitigated by 2-aminoethoxydiphenyl borate (2-APB) or BAPTA/AM.”

   Cellsrescue experiments

   Targeting NSUN2-Mediated m⁵C Modification Attenuates Chondrocyte Senescence and NLRP3 Activation in Osteoarthritis

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·6 Jul 2026

More on Ca2+ overload

1. 2-aminoethoxydiphenyl borate improves mitochondrial function in mouse cells.

   “Moreover, TRα knockdown cells exhibited increased Ca2+ transfer in MAM and mitochondrial dysfunction, which was ameliorated by the IP3R1 inhibitor 2-aminoethoxydiphenyl borate.”

   CellsTRα knockdown cellsC2C12

   Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca²⁺ Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice

   Cell proliferation·24 Aug 2025