11,12-eicosatrienoic acid
11,12-eicosatrienoic acid has been studied in 1 paper since 2016: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Apr 11, 2016: “11,12-Epoxyecosatrienoic acids mitigate endothelial dysfunction associated with estrogen loss and aging: Role of membrane depolarization”.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: American Heart Association and 4 more
- Animals1
What did studies of 11,12-eicosatrienoic acid find?
3Studies of 11,12-eicosatrienoic acid measured 3 outcomes; the most studied are endothelial-dependent dilation (1 study), NF-κB signaling (1) and inflammation (1).
Endothelial-dependent dilation
upin rats1
1 study
Endothelial-dependent dilation
upin rats1
11,12-eicosatrienoic acid improves endothelial-dependent dilation in rats.
“sEHi and 11,12-EET with or without E2 attenuated phenylephrine induced constriction and increased endothelial-dependent dilation of aortic rings from ovariectomized rats”
Animalswith or without E2 in ovariectomized ratsaorta
Journal of molecular and cellular cardiology
NF-κB signaling
no changein human cells1
1 study
NF-κB signaling
no changein human cells1
11,12-eicosatrienoic acid has no effect on NF-κB signaling in human cells.
“neither 11,12-EETs nor 17β-estradiol (E2) at physiologic concentrations prevented activation of NFκB by TNFα”
Cellswith TNFα
Journal of molecular and cellular cardiology
Inflammation
downin human cells1
1 study
Inflammation
downin human cells1
11,12-eicosatrienoic acid decreases inflammation in human cells.
“11,12-EET at a physiologically low dose (0.1nM) reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells (HAEC) and monocyte adhesion under shear flow”
Cellscombined with TNFα and stabilized by sEHiaorta0.1nM
Journal of molecular and cellular cardiology