1-ebio

1. 1-ebio decreases Klotho in mice.

   “significant decrease in total klotho concentration in the hippocampus but not in the prefrontal cortex or dorsal raphe”

   AnimalsIP, once dailyhippocampus1.0 mg/kg15 daysmales

   Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration

   Neuroscience applied·Dec 1, 2023

More on Klotho

1. 1-ebio has no effect on stress-coping behavior in mice.

   “The drug does not affect stress-coping behavior in the forced swim test.”

   AnimalsIP, once dailybrain1.0 mg/kg15 daysmales

   Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration

   Neuroscience applied·Dec 1, 2023

1. 1-ebio impairs cognitive function in mice.

   “chronic 1-EBIO treatment decreased locomotor activity, sucrose preference, and alternation index in an age-dependent manner.”

   AnimalsIP, once daily1.0 mg/kg15 daysmales

   Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration

   Neuroscience applied·Dec 1, 2023

1. 1-ebio decreases sucrose preference in mice.

   “chronic 1-EBIO treatment decreased locomotor activity, sucrose preference, and alternation index in an age-dependent manner.”

   AnimalsIP, once daily1.0 mg/kg15 daysmales

   Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration

   Neuroscience applied·Dec 1, 2023