1,25-dihydroxyvitamin d insufficiency
1,25-dihydroxyvitamin d insufficiency has been studied in 1 paper since 2020: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Feb 15, 2020: “1,25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence”.
1 paper studies it5 findingsUpdated
See all 1 papers on 1,25-dihydroxyvitamin d insufficiency
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Animals1
What did studies of 1,25-dihydroxyvitamin d insufficiency find?
5Studies of 1,25-dihydroxyvitamin d insufficiency measured 5 outcomes; the most studied are senescence-associated secretory phenotype (SASP) (1 study), cellular senescence (1) and DNA damage response (1).
Senescence-associated secretory phenotype (SASP)
upin mice1
1 study
Senescence-associated secretory phenotype (SASP)
upin mice1
1,25-dihydroxyvitamin d insufficiency increases senescence-associated secretory phenotype (SASP) in mice (Cyp27b1+/- mice compared with wild-type littermates).
“the expression levels of SASP molecules and p16, p19 and p53 proteins were all significantly increased in bone tissues”
AnimalsCyp27b1+/- mice compared with wild-type littermatesbone
American journal of translational research
Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
1,25-dihydroxyvitamin d insufficiency increases cellular senescence in mice (Cyp27b1+/- mice compared with wild-type littermates).
“inducing bone cell senescence and SASP”
AnimalsCyp27b1+/- mice compared with wild-type littermatesbone
American journal of translational research
DNA damage response
upin mice1
1 study
DNA damage response
upin mice1
1,25-dihydroxyvitamin d insufficiency increases DNA damage response in mice (Cyp27b1+/- mice compared with wild-type littermates).
“the parameters of oxidative stress and DNA damage were significantly increased”
AnimalsCyp27b1+/- mice compared with wild-type littermates
American journal of translational research
Oxidative stress and ROS signaling
upin mice1
1 study
Oxidative stress and ROS signaling
upin mice1
1,25-dihydroxyvitamin d insufficiency increases oxidative stress and ROS signaling in mice (Cyp27b1+/- mice compared with wild-type littermates).
“the parameters of oxidative stress and DNA damage were significantly increased”
AnimalsCyp27b1+/- mice compared with wild-type littermates
American journal of translational research
Age-related bone loss
upin mice1
1 study
Age-related bone loss
upin mice1
1,25-dihydroxyvitamin d insufficiency increases age-related bone loss in mice (Cyp27b1+/- mice).
“1,25(OH)2D insufficiency accelerates age-related bone loss by increasing oxidative stress and DNA damage”
AnimalsCyp27b1+/- micebone
American journal of translational research