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ZnT86D

Gene

1 paper studies it5 findings

Taxon

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Ministry of Science and ICT, South Korea and 2 more
  • Model organisms1

Effects

5

Amyloid-beta plaques

no changein flies1

1 study

  1. ZnT86D has no effect on amyloid-beta plaques in flies (without significant changes).

    “without significant changes in the deposition of amyloid beta plaques and susceptibility to oxidative stress”

    Model organismsknockdown of ZnT86D in the neurons of a Drosophila AD modelneurons

    Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model

    International journal of molecular sciences

Neurodegeneration

downin flies1

1 study

  1. ZnT86D protects against neurodegeneration in flies.

    “knockdown of ZnT86D in the neurons of a Drosophila AD model increased apoptosis and exacerbated neurodegeneration”

    Model organismsin a Drosophila AD modelneurons

    Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model

    International journal of molecular sciences

Apoptosis

downin flies1

1 study

  1. ZnT86D decreases apoptosis in flies.

    “knockdown of ZnT86D in the neurons of a Drosophila AD model increased apoptosis and exacerbated neurodegeneration”

    Model organismsin a Drosophila AD modelneurons

    Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model

    International journal of molecular sciences

More on Apoptosis

Locomotor activity

is required forin flies1

1 study

  1. ZnT86D is required for locomotor activity in flies (dramatically reduced).

    “When ZnT86D was silenced in neurons, the embryo-to-adult survival rate, locomotor activity, and lifespan were dramatically reduced.”

    Model organismsneuronal silencingneurons

    Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model

    International journal of molecular sciences

Lifespan

is required forin flies1

1 study

  1. ZnT86D is required for lifespan in flies (dramatically reduced).

    “When ZnT86D was silenced in neurons, the embryo-to-adult survival rate, locomotor activity, and lifespan were dramatically reduced.”

    Model organismsneuronal silencingneurons

    Roles of ZnT86D in Neurodevelopment and Pathogenesis of Alzheimer Disease in a Drosophila melanogaster Model

    International journal of molecular sciences

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