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ZHX3

Gene

1 paper studies it4 findings

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Animals1

Effects

3

CDKN2A

downin cells cells1downin mice1

1 study

  1. ZHX3 inhibits CDKN2A in mice.

    “Zhx3-knockout mice showed upregulation of p16INK4a in the testes, thymus and skeletal muscle tissues, together with relatively short survival periods in males.”

    AnimalsZhx3-knockouttestes, thymus, skeletal musclemales

    Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation

    PloS one

  2. ZHX3 inhibits CDKN2A in cells cells.

    “Loss of ZHX3 or ZHX3-interaction partners by knockdown similarly induced the expression of p16INK4a and rRNA genes.”

    Cellsknockdown

    Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation

    PloS one

More on CDKN2A

Lifespan

downin mice1

1 study

  1. ZHX3 shortens lifespan in mice.

    “relatively short survival periods in males”

    AnimalsZhx3-knockoutmales

    Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation

    PloS one

Cellular senescence

downin cells cells1

1 study

  1. ZHX3 prevents cellular senescence in cells cells.

    “loss of the zinc finger and homeobox protein 3 (ZHX3), a ubiquitously expressed transcription repressor, induced senescence-associated gene expression”

    Cellsloss of ZHX3

    Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation

    PloS one

More on Cellular senescence

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