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YPEL2

Gene

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Cells1

Effects

3

Cell adhesion

upin human cells1

1 study

  1. YPEL2 increases cell adhesion in human cells.

    “endothelial YPEL2 knockdown reduced H2O2-promoted THP-1 cell adhesion to HUVECs”

    Cellsin H2O2-treated HUVECs

    A novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathway

    Mechanisms of ageing and developmentMar 22, 2023

Cell viability

downin human cells1

1 study

  1. YPEL2 decreases cell viability in human cells.

    “reversed H2O2-inhibited cell viability”

    Cellsin H2O2-treated HUVECs

    A novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathway

    Mechanisms of ageing and developmentMar 22, 2023

Cellular senescence

upin human cells1

1 study

  1. YPEL2 increases cellular senescence in human cells.

    “Endothelial YPEL2 deficiency significantly decreased H2O2-increased senescence-associated beta-galactosidase (SA-β-gal) activity”

    Cellsin H2O2-treated HUVECs

    A novel role for YPEL2 in mediating endothelial cellular senescence via the p53/p21 pathway

    Mechanisms of ageing and developmentMar 22, 2023

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