Chronological lifespan
upin yeast cells1
YBT1 extends chronological lifespan in yeast cells.
“Notably, YBT1 overexpression extends CLS, mimicking SAH effects”
Cellsshown by YBT1 overexpression
Metabolic byproduct extended lifespan in yeast cells
Proceedings of the National Academy of Sciences of the United States of America16 Oct 2026
SAM sequestration into the vacuole
upin yeast cells1
YBT1 increases SAM sequestration into the vacuole in yeast cells.
“Ybt1 localizes to the vacuolar membrane and facilitates the sequestration of SAM from the cytosol into the vacuole.”
Cells
Metabolic byproduct extended lifespan in yeast cells
Proceedings of the National Academy of Sciences of the United States of America16 Oct 2026
Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.Experiments linked the effect to a brief burst of reactive oxygen molecules and a transporter protein called Ybt1.
Limit: Chronological lifespan captures nondividing cell survival, not the number of divisions cells can complete