USP16

1. USP16 improves memory and learning in mice.

   “can both ameliorate the NPC defect and rescue memory and learning through its regulation of both Cdkn2a and BMP signaling”

   Animalsvia reduction of USP16

   Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model

   eLife·Mar 21, 2022

1. USP16 decreases CDKN2A in mice.

   “Reduction of USP16 led to decreased expression of senescence gene Cdkn2a”

   Animalsvia genetic reduction

   Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model

   eLife·Mar 21, 2022

More on CDKN2A

1. USP16 decreases astrogliosis in mice.

   “reversing impaired NPC self-renewal via genetic reduction of USP16, a histone modifier and critical physiological antagonist of the Polycomb Repressor Complex 1, can prevent downstream cognitive defects and decrease astrogliosis in vivo”

   Animalsin an Alzheimer's disease mouse model

   Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model

   eLife·Mar 21, 2022

1. USP16 prevents cognitive defects in mice.

   “reversing impaired NPC self-renewal via genetic reduction of USP16, a histone modifier and critical physiological antagonist of the Polycomb Repressor Complex 1, can prevent downstream cognitive defects”

   Animalsin an Alzheimer's disease mouse model

   Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer's model

   eLife·Mar 21, 2022