USP13
1 paper4 findings
- 1 lab in 1 country
- Funders: National Heart, Lung, and Blood Institute and 1 more
- Cells1
Effects
2MDM2
downin human cells1downin mice1
1 study
MDM2
downin human cells1downin mice1
USP13 decreases MDM2 in human cells.
“Knockdown of USP13 increased MDM2 levels in lung cells, while overexpression of USP13 reduced it.”
Cellslung cells
USP13 regulates cell senescence through mediating MDM2 stability
Life sciencesAug 25, 2023
USP13 decreases MDM2 in mice.
“The increased protein levels of MDM2 were detected in lung tissues of USP13 deficient mice.”
Animalsshown by USP13 deficiencylung
USP13 regulates cell senescence through mediating MDM2 stability
Life sciencesAug 25, 2023
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
USP13 induces cellular senescence in human cells.
“Furthermore, overexpression of USP13 promoted cell senescence.”
Cellsoverexpression of USP13
USP13 regulates cell senescence through mediating MDM2 stability
Life sciencesAug 25, 2023
Associations
1MDM2
downin mice1
1 study
MDM2
downin mice1
USP13 is associated with MDM2 in mice.
“We found a negative correlation between USP13 and MDM2 expression in lung tissues of aged mice.”
Animalslung
USP13 regulates cell senescence through mediating MDM2 stability
Life sciencesAug 25, 2023
Latest
Life Sciences
USP13 regulates cell senescence through mediating MDM2 stability
Experiments in human cellsCellular senescence