trio
- 1 lab in 1 country
- Funders: National Institutes of Health and 1 more
- Model organisms1
Effects
4Synapse degeneration
downin flies1
1 study
Synapse degeneration
downin flies1
trio decreases synapse degeneration in flies.
“can also ameliorate synapse degeneration induced by depletion of miniature neurotransmission.”
Model organismsdepletion of miniature neurotransmission; increased Trio expressionmotor synapse
Trio preserves motor synapses and prolongs motor ability during aging
Cell reports24 May 2024
Capacity to sustain high-intensity neurotransmitter release
upin flies1
1 study
Capacity to sustain high-intensity neurotransmitter release
upin flies1
trio improves capacity to sustain high-intensity neurotransmitter release in flies.
“maintain the capacity of motor synapses to sustain high-intensity neurotransmitter release.”
Model organismsTrio overexpression during agingmotor synapse
Trio preserves motor synapses and prolongs motor ability during aging
Cell reports24 May 2024
Motor ability
upin flies1
1 study
Motor ability
upin flies1
trio improves motor ability in flies.
“increasing Trio expression in adult Drosophila can abrogate age-dependent synaptic structural fragmentation, postpone the decline of motor ability”
Model organismsTrio overexpression during aging
Trio preserves motor synapses and prolongs motor ability during aging
Cell reports24 May 2024
Age-dependent synaptic structural fragmentation
downin flies1
1 study
Age-dependent synaptic structural fragmentation
downin flies1
trio prevents age-dependent synaptic structural fragmentation in flies.
“increasing Trio expression in adult Drosophila can abrogate age-dependent synaptic structural fragmentation”
Model organismsTrio overexpressionmotor synapse
Trio preserves motor synapses and prolongs motor ability during aging
Cell reports24 May 2024