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TK1

Gene

2 papers study it6 findings

HGNCNCBI GeneTaxon

See all 2

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Guangxi Zhuang Autonomous Region Health and Family Planning Commission and 4 more
  • Cells2

Effects

4

IL-1β

upin human cells1

1 study

  1. TK1 increases IL-1β in human cells.

    “TK1 overexpression enhanced IL-1β expression, apoptosis, cell cycle arrest, and senescent phenotypes of SLE BMSCs”

    Cellsin SLE BMSCsbone marrow mesenchymal stem cells

    Identification of Novel Immune Cell-Relevant Therapeutic Targets and Validation of Roles of TK1 in BMSCs of Systemic Lupus Erythematosus

    Frontiers in molecular biosciences

More on IL-1β

Cell-cycle arrest

upin human cells1

1 study

  1. TK1 induces cell-cycle arrest in human cells.

    “TK1 overexpression enhanced IL-1β expression, apoptosis, cell cycle arrest, and senescent phenotypes of SLE BMSCs”

    Cellsin SLE BMSCsbone marrow mesenchymal stem cells

    Identification of Novel Immune Cell-Relevant Therapeutic Targets and Validation of Roles of TK1 in BMSCs of Systemic Lupus Erythematosus

    Frontiers in molecular biosciences

Apoptosis

upin human cells1

1 study

  1. TK1 induces apoptosis in human cells.

    “TK1 overexpression enhanced IL-1β expression, apoptosis, cell cycle arrest, and senescent phenotypes of SLE BMSCs”

    Cellsin SLE BMSCsbone marrow mesenchymal stem cells

    Identification of Novel Immune Cell-Relevant Therapeutic Targets and Validation of Roles of TK1 in BMSCs of Systemic Lupus Erythematosus

    Frontiers in molecular biosciences

More on Apoptosis

Cellular senescence

upin human cells1

1 study

  1. TK1 induces cellular senescence in human cells.

    “TK1 overexpression enhanced IL-1β expression, apoptosis, cell cycle arrest, and senescent phenotypes of SLE BMSCs”

    Cellsin SLE BMSCsbone marrow mesenchymal stem cells

    Identification of Novel Immune Cell-Relevant Therapeutic Targets and Validation of Roles of TK1 in BMSCs of Systemic Lupus Erythematosus

    Frontiers in molecular biosciences

More on Cellular senescence

Upstream

1

Cellular senescence

upin human cells1

1 study

  1. Cellular senescence increases TK1 in human cells.

    “increased expression of thymidine kinases (TK1) are prominent features of AC16 cells under doxorubicin induced senescence”

    Cellsdoxorubicin induced senescence

    Senescence in human AC16 cardiac cells is associated with thymidine kinase induction and histone loss

    microPublication biology

More on Cellular senescence

Associations

1

Systemic lupus erythematosus

upin human cells1

1 study

  1. Systemic lupus erythematosus is associated with TK1 in human cells.

    “TK1 expression was remarkably elevated in SLE BMSCs than controls.”

    Cellsin SLE BMSCs compared to controlsbone marrow mesenchymal stem cells

    Identification of Novel Immune Cell-Relevant Therapeutic Targets and Validation of Roles of TK1 in BMSCs of Systemic Lupus Erythematosus

    Frontiers in molecular biosciences

More on Systemic lupus erythematosus

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