There is 1 paper on TIA1E384KMUTATION in aging research: none in people yet, 1 in cells.
1 paper studies it2 findings
See all 1 papers on TIA1E384KMUTATION
At a glance
The findings reach cells, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Barndiabetesfonden and 6 more
- Cells1
Effects
2Insulin content and release
downin human cells1
1 study
Insulin content and release
downin human cells1
TIA1E384KMUTATION decreases insulin content and release in human cells (homozygous E384K TIA1 mutation versus wild-type).
“a proinsulin-to-insulin processing defect, a decreased insulin content and release”
Cellshomozygous E384K TIA1 mutation versus wild-typeEndoC-βH1 cells
The Journal of biological chemistry
β-cell dedifferentiation
upin human cells1
1 study
β-cell dedifferentiation
upin human cells1
TIA1E384KMUTATION induces β-cell dedifferentiation in human cells (homozygous E384K TIA1 mutation).
“It is concluded that the TIA1 E384K mutation, via increased MYC levels and cell proliferation rates, causes beta cell dedifferentiation.”
Cellshomozygous E384K TIA1 mutationEndoC-βH1 cells
The Journal of biological chemistry