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SUPV3L1

Gene

2 papers5 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: National Institutes of Health and 5 more
  • Animals2

Effects

4

Skin barrier

is required forin mice1

1 study

  1. SUPV3L1 is required for skin barrier in mice.

    “Together, these data indicate that Supv3L1 is important for the maintenance of the skin barrier.”

    Animalskeratinocytesskin

    Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death

    Mammalian genome : official journal of the International Mammalian Genome Society15 Jan 2009

Adipose tissue

downin mice1

1 study

  1. SUPV3L1 decreases adipose tissue in mice.

    “Disruption mediated by a Mx1 promoter-driven Cre displayed a postnatal growth delay, reduced lifespan, loss of adipose tissue and muscle mass”

    Animalsdisruption mediated by Mx1-Creadipose tissue

    Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death

    Mammalian genome : official journal of the International Mammalian Genome Society15 Jan 2009

Muscle mass

downin mice1

1 study

  1. SUPV3L1 decreases muscle mass in mice.

    “Disruption mediated by a Mx1 promoter-driven Cre displayed a postnatal growth delay, reduced lifespan, loss of adipose tissue and muscle mass”

    Animalsdisruption mediated by Mx1-Creskeletal muscle

    Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death

    Mammalian genome : official journal of the International Mammalian Genome Society15 Jan 2009

Lifespan

downin mice1

1 study

  1. SUPV3L1 shortens lifespan in mice.

    “Disruption mediated by a Mx1 promoter-driven Cre displayed a postnatal growth delay, reduced lifespan, loss of adipose tissue and muscle mass”

    Animalsdisruption mediated by Mx1-Cre

    Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death

    Mammalian genome : official journal of the International Mammalian Genome Society15 Jan 2009

Associations

1

Breast cancer

downin humans1

1 study

  1. Breast cancer is associated with SUPV3L1 in humans.

    “reduced SUV3 expression was observed in human breast tumor specimens compared with corresponding normal tissues in two independent cohorts.”

    Humansbreast tumor

    Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan

    Oncogene7 May 2012

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