SUB1

1. SUB1 induces cellular senescence in mouse cells.

   “Sub1 interacted with TAF9b and AROS to stabilize p53 by regulating its ubiquitination and acetylation, thereby promoting cardiomyocyte senescence.”

   Cellscardiomyocytes

   Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice

   Nature communications·6 Jul 2026

More on Cellular senescence

1. SUB1 increases heart failure with preserved ejection fraction in mice.

   “Sub1 knockdown delays cardiac aging and alleviates HFpEF features, even when initiated in aged mice.”

   Animals

   Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice

   Nature communications·6 Jul 2026

More on Heart failure with preserved ejection fraction

1. SUB1 increases diastolic dysfunction in mice.

   “Cardiac overexpression of Sub1 shortens lifespan, exacerbates diastolic dysfunction, and accelerates cardiac aging”

   Animalsheart

   Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice

   Nature communications·6 Jul 2026

1. SUB1 shortens lifespan in mice.

   “Cardiac overexpression of Sub1 shortens lifespan, exacerbates diastolic dysfunction, and accelerates cardiac aging”

   Animalsheart

   Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice

   Nature communications·6 Jul 2026