STX4A

1. STX4A increases oxidative phosphorylation in mice.

   “Mechanistically, STX4 deficiency reduces oxidative phosphorylation, glucose uptake, and glycolysis leading to reduced ATP levels, a known triggering signal for pyroptosis.”

   Animalsin brown adipocytesbrown adipose tissue

   Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway

   Nature communications·Apr 2, 2024

More on Oxidative phosphorylation

1. STX4A inhibits pyroptosis in mice.

   “Similar to aged brown adipocytes, Ucp1-STX4KO mice display loss of brown adipose tissue mass and thermogenic dysfunction concomitant with increased pyroptosis.”

   Animalsin Ucp1-STX4KO micebrown adipose tissue

   Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway

   Nature communications·Apr 2, 2024

More on Pyroptosis

1. STX4A protects against brown adipose tissue mass in mice.

   “Restoration of STX4 expression or suppression of pyroptosis activation protects against the decline in both mass and thermogenic activity in the aged and Ucp1-STX4KO mice.”

   Animalsin aged and Ucp1-STX4KO micebrown adipose tissue

   Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway

   Nature communications·Apr 2, 2024