STIP1
- 1 lab in 1 country
- Funders: ALS Society of Canada and 3 more
- Humans2
- Animals1
- Model organisms1
Effects
2Mislocalized TDP-43
downin mice1
1 study
Mislocalized TDP-43
downin mice1
STIP1 decreases mislocalized TDP-43 in mice.
“reducing the activity of STI1, an Hsp90 co-chaperone, was associated with reduced mislocalized TDP-43 in the brain and spinal cord and partially rescued some motor deficits.”
Animalsin human wild-type TDP-43 overexpression ALS mouse modelbrain and spinal cord
Journal of neurochemistry
Lifespan
downin mice1
1 study
Lifespan
downin mice1
STIP1 shortens lifespan in mice.
“overexpressing STI1 seemed to be deleterious, exacerbating the levels of C-terminal TDP-43 fragments in the cytoplasm, worsening motor abnormalities and reducing lifespan.”
Animalsin human wild-type TDP-43 overexpression ALS mouse modelcentral nervous system
Journal of neurochemistry
Latest
3 papers in 12 monthsClinical Epigenetics
Age-varying DNA methylation patterns associated with blood pressure in mid-to-late adulthood
Cohort study of 976 peopleDNA methylation
Neurotoxicology
The protein co-chaperone STI-1 impacts motor function in C. elegans upon developmental methylmercury exposure
Experiments in wormsOxidative phosphorylation
bioRxiv
Age-varying DNA methylation patterns associated with blood pressure across the lifespan
Preprint: cohort study of 976 peopleDNA methylation
Journal of Neurochemistry
A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits
Experiments in miceMechanisms