Mislocalized TDP-43
1 paper studies it2 more mention it1 finding
- Animals1
Upstream
1STIP1
downin mice1
1 study
STIP1
downin mice1
STIP1 decreases mislocalized TDP-43 in mice.
“reducing the activity of STI1, an Hsp90 co-chaperone, was associated with reduced mislocalized TDP-43 in the brain and spinal cord and partially rescued some motor deficits.”
Animalsin human wild-type TDP-43 overexpression ALS mouse modelbrain and spinal cord
Journal of neurochemistry
Latest
Journal of Neurochemistry
A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits
Experiments in miceMechanisms
Acta Neuropathologica Communications
Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence
Experiments in miceDNA repair
Acta Neuropathologica Communications
Clusterin protects neurons against intracellular proteotoxicity
Experiments in model organismsInterventions