ST8SIA6
There is 1 paper on ST8SIA6 in aging research: none in people yet, 1 in animals.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: Medizinische Hochschule Hannover
- Animals1
Effects
4Anti-nuclear IgG autoantibodies
downin mice1
1 study
Anti-nuclear IgG autoantibodies
downin mice1
ST8SIA6 decreases anti-nuclear IgG autoantibodies in mice (Shown by St8sia6 knockout).
“aged St8sia6-/- mice exhibited increased activation markers on their B cells and displayed elevated levels of anti-nuclear IgG autoantibodies”
AnimalsShown by St8sia6 knockout
Frontiers in immunology
Germinal center B cell, age-induced B cell, and plasma cell populations
downin mice1
1 study
Germinal center B cell, age-induced B cell, and plasma cell populations
downin mice1
ST8SIA6 decreases germinal center B cell, age-induced B cell, and plasma cell populations in mice (Shown by St8sia6 knockout).
“In the study, 60-week-old St8sia6-/- mice showed enlarged populations of germinal center B cells, age-induced B cells, and plasma cells.”
AnimalsShown by St8sia6 knockout
Frontiers in immunology
More on Germinal center B cell, age-induced B cell, and plasma cell populations
IgG1 response
downin mice1
1 study
IgG1 response
downin mice1
ST8SIA6 decreases IgG1 response in mice (Shown by St8sia6 knockout following T cell-dependent immunization).
“Additionally, an increased IgG1 response was observed upon T cell-dependent immunization.”
AnimalsShown by St8sia6 knockout following T cell-dependent immunization
Frontiers in immunology
B cell proliferation
downin mice1
1 study
B cell proliferation
downin mice1
ST8SIA6 decreases B cell proliferation in mice (Shown by St8sia6 knockout under T cell-dependent stimulation).
“However, in St8sia6-/- B cells, a stronger proliferation was induced by T cell-dependent stimuli.”
AnimalsShown by St8sia6 knockout under T cell-dependent stimulationB cell
Frontiers in immunology