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SOX17

Gene

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Heart Association and 4 more
  • Animals2
  • Cells1

Effects

3

Pulmonary arterial hypertension

downin rats1

1 study

  1. SOX17 decreases pulmonary arterial hypertension in rats.

    “attenuated pulmonary vascular remodeling, and alleviated PAH severity”

    Animalsin PAH rat modelslung

    SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension

    Research squareJul 29, 2025Preprint

More on Pulmonary arterial hypertension

Cellular senescence

downin rats1

1 study

  1. SOX17 decreases cellular senescence in rats.

    “SOX17 overexpression, which leads to upregulation of Nestin and downregulation of p16INK4a in lungs of PAH rat models, significantly reduced PAEC senescence”

    Animalsin PAH rat modelslung

    SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension

    Research squareJul 29, 2025Preprint

More on Cellular senescence

NES

upin human cells1

1 study

  1. SOX17 activates NES in human cells.

    “SOX17), a transcription factor known to be associated with PAH, activated Nestin expression by binding directly to the Nestin promoter”

    Cellsin PAECspulmonary arterial endothelial cells

    SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension

    Research squareJul 29, 2025Preprint

More on NES

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