There are 3 papers on SMAD6 in aging research: 1 observational study in people, 2 in cells.
At a glance
The findings reach cells, none yet in people. 1 lab in 1 country.
Cells: a single group. Worms or flies, mice and humans: nothing yet.
- 1 lab in 1 country
- Funders: Japan Science and Technology Agency and 3 more
- Humans1
- Cells2
Effects
1Cellular senescence
downin mouse cells1
1 study
Cellular senescence
downin mouse cells1
SMAD6 inhibits cellular senescence in mouse cells (shown by induction/overexpression).
“senescence was also bypassed by Smad6 induction in Raf-activated cells”
Cellsshown by induction/overexpression
Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence
World journal of biological chemistry
Latest
Clinical Epigenetics
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals
Study in peopleBariatric surgery
PNAS
BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence
Experiments in human cellsCellular senescence
World Journal of Biological Chemistry
Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence
Experiments in mouse cellsTGF-β signaling