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slc-25A26

Gene

1 paper2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Ministry of Education, India and 3 more
  • Model organisms1

Effects

2

Mitochondrial unfolded protein response

upin worms1

1 study

  1. slc-25A26 activates mitochondrial unfolded protein response in worms.

    “RNAi knockdown of SLC-25A26, a carrier protein responsible for transporting SAM from the cytoplasm into the mitochondria, significantly lowers the mitochondrial SAM levels and activates UPRmt”

    Model organismsRNAi knockdown

    Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans

    Aging cell15 Feb 2024

More on Mitochondrial unfolded protein response

Mitochondrial SAM levels

downin worms1

1 study

  1. slc-25A26 decreases mitochondrial SAM levels in worms.

    “RNAi knockdown of SLC-25A26, a carrier protein responsible for transporting SAM from the cytoplasm into the mitochondria, significantly lowers the mitochondrial SAM levels”

    Model organismsRNAi knockdown

    Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans

    Aging cell15 Feb 2024

More on Mitochondrial SAM levels

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