Mitochondrial SAM levels

1. slc-25A26 decreases mitochondrial SAM levels in worms.

   “RNAi knockdown of SLC-25A26, a carrier protein responsible for transporting SAM from the cytoplasm into the mitochondria, significantly lowers the mitochondrial SAM levels”

   Model organismsRNAi knockdown

   Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans

   Aging cell·15 Feb 2024

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1. sams-1 decreases mitochondrial SAM levels in worms.

   “depleting SAMS-1 markedly decreases mitochondrial SAM levels”

   Model organismsdepleting SAMS-1

   Mitochondrial S-adenosylmethionine deficiency induces mitochondrial unfolded protein response and extends lifespan in Caenorhabditis elegans

   Aging cell·15 Feb 2024

More on sams-1