Sh

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funder: National Institutes of Health

Model organisms2

Effects

Cardiac function

is required forin flies1downin flies1

1 study

Sh is required for cardiac function in flies.
“neuronal knockdown alone impaired cardiac behavior, supporting a functional neurocardiac regulatory axis mediated by Shaker-dependent electrical signaling”
Model organismsneuron
Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila
Biogerontology18 Jan 2026
Sh impairs cardiac function in flies.
“Shmns mutants exhibited progressive cardiac decline with age, including increased heart period, elevated arrhythmicity, extended systolic and diastolic intervals, reduced contraction rate, and overall impaired cardiac output”
Model organisms
Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila
Biogerontology18 Jan 2026