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Cells1

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Oncogene·16 Dec

Phosphorylation of CBX8 by PKD1 suppresses PRC1 activity and promotes cell senescence

Experiments in human cellsCellular senescence

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BMI11
CBX81
CDKN2A1
Cellular senescence1
Chromatin1
Epigenetic regulation of gene expression1
H2AK119ub11
H3K27me31
Histone modification and chromatin remodelling1
PRKD11
Ubiquitin–proteasome system1
p16INK4a–RB pathway1

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Trials

AKG and Brain Health in AgingPhase 2Registered 6 Oct 2026, University of Oklahoma Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)Phase 1Registered 2 Oct 2026, Vinmec Research Institute of Stem Cell and Gene Technology AI-Based Conversational Social Support for Older Adults With Heart FailureRegistered 7 Oct 2026, Chang Gung University of Science and Technology

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Mechanisms267 Interventions486 Biomarkers448 Populations636 AI & data173 Industry & policy24

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