The Lancet Neurology
DNA variants linked to inherited Alzheimer’s disease risk
One DNA variant was associated with higher disease odds, with an odds ratio of 11.99, when 101 symptomatic mutation carriers were compared with 5,050 unaffected controls.One DNA variant was associated with higher disease odds, with an odds ratio of 11.99, when 101 symptomatic mutation carriers were compared with 5,050 unaffected controls.
Genetic association · 5,151 peopleMechanisms
Who was studied5,151 non-Hispanic White ADAD cases and controls
What changedInherited Alzheimer’s disease risk was higher with the CNIH4 variant than without it (odds ratio 11·99)
The catchOnly 101 symptomatic cases, raising concerns about inflated CNIH4 risk estimates