What does the research say about PROX1?

PROX1

There are 9 papers on PROX1 in aging research: 2 observational studies in people, 5 in animals, 1 in cells. The newest story, Oct 26, 2026: “An immune cell molecule promotes stroke recovery in mice”.

Gene

9 papers study it1 finding

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 9 papers on PROX1

At a glance

The findings reach mice, none yet in people. 1 lab.

1 lab

Funders: BrightFocus Foundation and 3 more

Humans2
Animals5
Cells1
In silico1

Effects

Intraocular pressure

downin mice1

1 study

PROX1 decreases intraocular pressure in mice (shown by selective Prox1 deletion).
“Within four weeks, intraocular pressure significantly increased, and ocular hypertension was maintained for at least 24 weeks.”
Animalsshown by selective Prox1 deletionSchlemm's canalwithin four weeks
PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension
bioRxiv : the preprint server for biologyNov 14, 2025Preprint

Latest

1 paper in 12 months

ESC Congress 2026 AbstractOct 26

An immune cell molecule promotes stroke recovery in mice

In mice with induced stroke, guanosine secreted by regulatory T cells promoted meningeal lymphatic growth and fluid drainage to improve recovery.In mice with induced stroke, guanosine secreted by regulatory T cells promoted meningeal lymphatic growth and fluid drainage to improve recovery.

Mouse studyBlood and immune system