There are 2 papers on PROM2 in aging research: 2 observational studies in people.
At a glance
The findings reach people, from one lab or study. 1 lab in 1 country.
“was increased in atrial samples of patients with HF with preserved ejection fraction”
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and 4 more
- Humans2
Effects
2Cardiomyocyte hypertrophy
upin cells1
1 study
Cardiomyocyte hypertrophy
upin cells1
PROM2 induces cardiomyocyte hypertrophy in cells (Prom2 overexpression in cardiac cells).
“Prom2 overexpression was sufficient to drive senescence, hypertrophy and resistance to cytotoxic stress”
CellsProm2 overexpression in cardiac cellscardiomyocytes
Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart
Aging cell
Cellular senescence
upin cells1
1 study
Cellular senescence
upin cells1
PROM2 induces cellular senescence in cells (Prom2 overexpression in cardiac cells).
“Prom2 overexpression was sufficient to drive senescence, hypertrophy and resistance to cytotoxic stress”
CellsProm2 overexpression in cardiac cellscardiomyocytes
Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart
Aging cell
Upstream
1TP53
upin cells1
1 study
TP53
upin cells1
TP53 activates PROM2 in cells (stress-induced premature senescence).
“Prom2 was upregulated by a p53-dependent pathway in stress-induced premature senescence.”
Cellsstress-induced premature senescence
Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart
Aging cell
Associations
2Heart failure with preserved ejection fraction
upin humans1
1 study
Heart failure with preserved ejection fraction
upin humans1
PROM2 is associated with heart failure with preserved ejection fraction in humans (heart failure with preserved ejection fraction).
“was increased in atrial samples of patients with HF with preserved ejection fraction”
Humansheart failure with preserved ejection fractionatrium
Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart
Aging cell
Cardiomyocyte aging
upin mice1
1 study
Cardiomyocyte aging
upin mice1
PROM2 is associated with cardiomyocyte aging in mice (aged versus young mice).
“We identified Prominin2 (Prom2), encoding a transmembrane glycoprotein, as the most upregulated gene in cardiomyocytes of aged mice compared to young mice.”
Animalsaged versus young micecardiomyocytes
Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart
Aging cell