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PREP1

There is 1 paper on PREP1 in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it3 findings

HGNCNCBI GeneTaxon

See all 1 papers on PREP1

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Associazione Italiana per la Ricerca sul Cancro and 1 more
  • Animals1

Effects

2

Apoptosis

mediatesin mouse cells1downin mouse cells1

1 study

  1. PREP1 mediates apoptosis in mouse cells.

    “the synthetic Prep1 inhibitory peptide Prep1 (54-72) reduced the antiapoptotic effects mediated by IL-6, particularly in senescent VSMCs”

    CellsIL-6-mediated antiapoptotic effect, tested with Prep1 (54-72) peptide, particularly in senescent VSMCsvascular smooth muscle cell

    Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

  2. PREP1 decreases apoptosis in mouse cells (shown by Prep1 overexpression in VSMCs) (25% decrease in apoptosis; caspase 3 down 40%, caspase 9 down 37%).

    “Prep1 overexpression in VSMCs decreased apoptosis by 25% and caspase 3 and caspase 9 expression by 40% and 37%.”

    Cellsshown by Prep1 overexpression in VSMCsvascular smooth muscle cell

    Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Apoptosis

Medial smooth muscle cell density

upin mice1

1 study

  1. PREP1 increases medial smooth muscle cell density in mice (shown by Prep1 hypomorphic heterozygous mice (Prep1i/+)) (25% reduction in Prep1i/+ compared with WT).

    “Histological analysis from Prep1i/+ aortas revealed a 25% reduction in medial smooth muscle cell density compared to WT animals.”

    Animalsshown by Prep1 hypomorphic heterozygous mice (Prep1i/+)aorta

    Interleukin 6 reduces vascular smooth muscle cell apoptosis via Prep1 and is associated with aging

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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