PPP2R2A

1. PPP2R2A inhibits NAD+ metabolism in mouse cells.

   “PPP2R2A deficiency promotes NAD+ biosynthesis through the nicotinamide riboside (NR)-directed salvage pathway in T cells.”

   CellsPPP2R2A deficiency in T cells

   The PP2A regulatory subunit PPP2R2A controls NAD⁺ biosynthesis to regulate T cell subset differentiation in systemic autoimmunity

   Cell reports·Jun 16, 2024

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1. PPP2R2A inhibits CDKN2A in human cells.

   “ectopic PR55α expression in normal pancreatic cells inhibits p16 transcription”

   Cellsin normal pancreatic cellspancreas

   PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

   Aging·Mar 4, 2024

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1. PPP2R2A inhibits cellular senescence in human cells.

   “ectopic PR55α expression in normal pancreatic cells inhibits p16 transcription, increases RB phosphorylation, and blocks IR-induced senescence.”

   Cellsin normal pancreatic cellspancreas

   PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

   Aging·Mar 4, 2024

More on Cellular senescence

1. PPP2R2A is associated with CDKN2A in human cells.

   “In normal human tissues, levels of p16 and PR55α proteins were inversely correlated and mutually exclusive.”

   Cellsin normal human tissues

   PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

   Aging·Mar 4, 2024

More on CDKN2A